How Long Do Polynucleotide Results Last?

In the evolving world of aesthetic and skin rejuvenation treatments, polynucleotides have emerged as a breakthrough innovation — often praised as the next generation of skin boosters. Unlike traditional injectables that focus on instant results, polynucleotides work on a deeper, cellular level to repair, hydrate, and renew the skin from within. You’ve probably seen impressive polynucleotide before-and-after transformations online, showing smoother texture, improved elasticity, and a radiant glow.

So, how long do polynucleotide results last? On average, the results can last between 6 to 12 months, depending on your skin type, lifestyle, and aftercare routine. Some people notice longer-lasting improvements with consistent maintenance sessions.

What makes this treatment stand out is its natural regenerative effect. Instead of simply filling wrinkles, polynucleotide injections encourage your skin to produce collagen, improve hydration, and repair damaged cells — meaning your skin continues to improve even weeks after the treatment. In short, it’s not just about looking better instantly; it’s about helping your skin function better over time.

What Are Polynucleotides and How Do They Work?

Polynucleotides (PNs) are natural, biocompatible DNA fragments that come primarily from salmon or trout. Despite the fish origin, these molecules are highly purified and completely safe for human use. What makes them revolutionary is their ability to repair and rejuvenate skin at a cellular level, rather than simply adding volume or paralysing muscles.

When polynucleotides are injected into the dermis, they trigger multiple biological processes:

• Cellular Regeneration: Polynucleotides stimulate the activity of fibroblasts, the skin cells responsible for producing collagen and elastin.
• Improved Hydration: They enhance skin hydration by stimulating the synthesis of hyaluronic acid, thereby improving elasticity and radiance.
• Antioxidant Effect: Polynucleotides neutralise free radicals, reducing oxidative stress and protecting the skin from environmental ageing.
• Tissue Repair: They accelerate healing and help restructure damaged skin, making them beneficial for scars, fine lines, and sun-damaged areas.

Unlike hyaluronic acid fillers, which restore lost volume, polynucleotide treatments initiate a biorevitalization process, repairing the skin from the inside out. Over time, the skin looks more even-toned, youthful, and plump, with an overall improvement in health and texture.

When Do Polynucleotide Results Start to Show?

Polynucleotide treatments do not produce instant results like fillers. Instead, they work with your body’s natural biology, which means improvement happens gradually as your skin regenerates.

Here’s a general timeline of what you can expect:

• Days 1–7: Mild swelling and redness may occur. Some people notice subtle hydration or smoothness early on.
• Weeks 2–3: Cellular regeneration begins. The skin may feel firmer and look slightly more radiant.
• Weeks 4–6: Collagen production becomes more noticeable; fine lines and dullness start to fade.
• Weeks 6–12: Full results typically appear. The skin looks brighter, tighter, and more youthful.

Patience is key with polynucleotide injections. Because they are designed to improve skin quality, not just appearance, they offer results that last longer and look far more natural.

For most patients, visible improvement begins around 3–4 weeks post-treatment, and the skin continues to improve over the next few months as new collagen develops.

How Long Do Polynucleotide Results Last?

On average, the results of a polynucleotide treatment last between 6 to 12 months. The longevity of your skin depends on several factors, including your skin type, age, and lifestyle habits.

• For the under-eye area, where the skin is thinner, results typically last about 6 months.
• For facial and neck treatments, many patients enjoy results that last up to 12 months or longer, provided they maintain proper care.

What makes polynucleotides stand out is that the improvement doesn’t disappear overnight; it fades gradually as your skin’s natural renewal slows down again. Because the treatment works by stimulating collagen regeneration, your skin continues to benefit from the effects even after the visible results start to lessen.

Key highlights:

• Initial visible results are typically seen within 3–6 weeks.
• Full results: after 2–3 sessions.
• Longevity: 6–12 months, depending on maintenance.
• Ongoing collagen renewal results in subtle, lasting improvements.

While the polynucleotide treatment cost may initially seem higher than that of traditional fillers, the long-lasting and regenerative results often make it more cost-effective in the long run.

Factors That Affect How Long Polynucleotides Last

Several internal and external factors influence the longevity of polynucleotide treatment results. Understanding these can help you maximise and maintain your skin’s rejuvenation outcome.

Age: Younger individuals generally have a more active collagen cycle, which can lead to longer-lasting effects.
Skin Type & Damage: Those with sun-damaged, dry, or dehydrated skin may require additional sessions to achieve optimal and lasting results.
Lifestyle Habits: Smoking, stress, and an unbalanced diet can accelerate collagen breakdown, shortening the visible effects of the treatment.
Sun Exposure: UV rays are one of the most significant factors in reducing treatment longevity. Consistent sun protection is essential.
Skincare Routine: Using SPF daily, incorporating antioxidants, and maintaining a gentle yet effective skincare routine can greatly preserve your results.
Treatment Frequency: Regular maintenance sessions every 6–9 months help sustain your skin’s improved tone, texture, and firmness.

At Charisma Beauty Lounge, our specialists guide you through tailored aftercare and lifestyle tips to help you get the most from your treatment. For example, someone who protects their skin daily and stays hydrated will enjoy smoother, longer-lasting results compared to someone who frequently tans or smokes.

Maintenance Treatments: Keeping the Glow Alive

A key advantage of polynucleotide injections is that they can be easily maintained without over-treating your skin.

A typical protocol includes:

• Initial phase: 2–3 sessions spaced 3–4 weeks apart for best collagen stimulation.
• Maintenance phase: One session every 6–9 months, depending on your individual response to treatment.

For delicate areas, such as the under-eye area, small maintenance top-ups may be recommended every 4–6 months to maintain smoothness and hydration.

These ongoing sessions ensure that your skin continues to produce fresh collagen and elastin, keeping it supple and firm throughout the year.

How to Prolong Polynucleotide Results Naturally

To make your polynucleotide treatment last longer and maintain your skin’s glow, follow these dermatologist-approved habits:

• Stay Hydrated: Drink 2–3 litres of water daily to support skin regeneration.
• Use SPF Every Day: Protect your skin from UV-induced collagen breakdown.
• Eat Antioxidant-Rich Foods: Include berries, nuts, and leafy greens to combat oxidative stress.
• Avoid Smoking and Alcohol: Both slow collagen production and dehydrate the skin.
• Use a Gentle Skincare Routine: Focus on ceramide-rich moisturisers and avoid harsh exfoliants.
• Incorporate Hyaluronic Acid Serums: Enhance hydration and elasticity.
• Get Enough Sleep: Skin repairs itself during rest. Poor sleep can dull results.

Following these steps not only extends the lifespan of polynucleotides but also maintains the overall quality of your skin between treatments.

Comparing Polynucleotides with Other Aesthetic Treatments

Polynucleotides are often compared with other rejuvenation methods, such as fillers, PRP (Platelet-Rich Plasma), and standard skin booster treatments.

Here’s how they differ:

• Dermal Fillers: Provide instant volume but don’t enhance skin quality; results fade in 6–9 months.
• PRP (Platelet-Rich Plasma): Uses your blood’s platelets to stimulate healing; results depend on platelet concentration.
• Skin Booster Polynucleotides: Go deeper, repairing skin cells and restoring hydration and elasticity from within.

Polynucleotides offer a more regenerative and natural approach, creating a healthier foundation for long-term youthfulness rather than relying on quick cosmetic fixes.

Are Polynucleotides Safe? Possible Side Effects and Aftercare

Polynucleotide injections are known for their excellent safety profile and biocompatibility. Because they use DNA sequences similar to those found in human tissue, allergic reactions are rare. However, as with any injection-based treatment, minor temporary side effects can occur.

Common and mild effects:

• Redness or swelling at the injection site
• Small raised polynucleotide bumps that disappear in 1–2 days
• Light bruising or tenderness

Aftercare Tips:

• Avoid touching or applying makeup for 24 hours.
• Keep the area clean and avoid exposure to heat (such as saunas and steam) for 48 hours.
• Apply SPF daily and avoid direct sun exposure.
• Use gentle moisturisers to support skin recovery.

By following aftercare guidelines, you’ll help your skin heal faster and ensure that polynucleotide results appear evenly and beautifully.

What Happens If You Don’t Maintain Polynucleotide Treatments?

If you skip maintenance sessions, your skin won’t suddenly revert to its original state. However, over several months, collagen levels will slowly decline again, and the effects will fade.

You’ll still retain some benefits, especially improved skin texture and hydration. However, for ongoing firmness and glow, regular top-up sessions are recommended every 6 to 9 months.

Think of polynucleotides like skincare: consistent upkeep leads to lasting transformation.

Common Myths About Polynucleotide Longevity

Let’s clear up a few misconceptions:

• Myth 1: Polynucleotides give instant results.
• False — results develop over weeks as collagen regenerates.
• Myth 2: One treatment is enough.
• False — most people need 2–3 sessions for visible improvement.
• Myth 3: Results are permanent.
• False — results typically last 6–12 months, though collagen stimulation continues beyond that.
• Myth 4: Polynucleotides are the same as fillers.
• False — fillers add volume, while polynucleotides heal and rejuvenate skin.
• Myth 5: Polynucleotides don’t work.
• False — multiple clinical studies show improved hydration, elasticity, and wrinkle reduction.

Conclusion

Polynucleotides have redefined non-surgical skin rejuvenation. They don’t just hide the signs of ageing, they address them at a cellular level by restoring hydration, collagen, and elasticity.

Here’s what we know:

• Results appear gradually over several weeks.
• Longevity ranges from 6 to 12 months, depending on the level of care and the individual’s skin type.
• Maintenance and healthy lifestyle habits extend results.

Whether you’re focusing on polynucleotide under-eye treatments, full-face rejuvenation, or microneedling combinations, this therapy delivers natural, regenerative, and long-lasting improvements.how