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The skin beneath our eyes is one of the most delicate and vulnerable areas on the face. It is thinner, contains fewer oil glands, and is more prone to showing signs of fatigue, ageing, and dehydration. Fine lines, puffiness, and dark circles can make the face appear tired or older than it truly is. While traditional cosmetic treatments such as fillers and creams may offer temporary relief, they often fail to address the root cause of under-eye ageing — cellular damage and reduced collagen production.
This is where Polynucleotide treatment has become a breakthrough solution in modern aesthetic medicine. Rather than simply filling or tightening the skin, Polynucleotides work at a cellular level to repair, restore, and rejuvenate the skin’s natural structure.
Polynucleotides (PNs) are long chains of nucleotides — the essential building blocks of DNA and RNA. These molecules are derived from highly purified, biocompatible DNA, typically sourced from salmon or trout because their DNA closely resembles that of humans.
When used in aesthetic treatments, Polynucleotides serve as bio-revitalising agents, meaning they help the skin repair itself naturally. They don’t alter facial structure or expression; instead, they encourage the skin’s own biological processes to produce healthier, more youthful tissue.
Unlike hyaluronic acid fillers, which add immediate volume, Polynucleotides stimulate deep tissue regeneration over time. Once injected into the dermal layer, these molecules begin a cascade of biological processes that renew and strengthen the skin.
Here’s how they work:
Over several weeks, the under-eye area becomes brighter, firmer, and smoother, with reduced signs of fatigue and ageing.
Polynucleotide therapy is rooted in regenerative medicine, which focuses on stimulating the body’s natural ability to heal itself. The science behind it is based on tissue bio-stimulation and DNA repair mechanisms.
When Polynucleotides are injected into the skin, they trigger three key biological responses:
Fibroblasts are the cells responsible for producing collagen and elastin, two proteins that maintain the skin’s firmness and elasticity. Polynucleotides activate these fibroblasts, increasing the density and quality of collagen fibres. The result is tighter, more youthful-looking skin.
The DNA fragments in Polynucleotides encourage cell turnover, replacing damaged or aged cells with new, healthy ones. This accelerates the skin’s natural healing process, especially useful for thin under-eye skin that tends to lose elasticity with age.
Through these combined mechanisms, Polynucleotide treatment not only hides the symptoms of ageing, but also reverses the underlying causes of skin fatigue and sagging.
The under-eye region requires a delicate approach. Traditional fillers can sometimes cause puffiness, uneven texture, or a “filled” appearance if not administered precisely. Polynucleotides, however, integrate smoothly within the skin without adding unnecessary volume.
Instead of filling, they heal and restore — making them ideal for:
The under-eye region is one of the first areas to show signs of ageing. Due to constant facial movement, thin skin, and decreased collagen production, many people experience fine lines, puffiness, and dark circles early in life. Polynucleotide treatment directly addresses these concerns at the cellular level, offering natural and long-lasting rejuvenation.
Let’s explore the significant benefits of this advanced regenerative treatment for the under-eye area.
Fine lines beneath the eyes often appear due to collagen breakdown and repetitive facial expressions. Polynucleotides promote fibroblast activity, the cells responsible for generating new collagen and elastin fibres.
Over time, this process restores the skin’s natural structure, leading to a visible reduction in fine lines and wrinkles. The skin appears smoother, tighter, and more youthful — without the overfilled effect that some fillers can cause.
This makes Polynucleotide treatment particularly beneficial for people who want to maintain a natural expression while achieving anti-ageing effects.
Dark circles are one of the most common under-eye concerns, often caused by poor blood circulation, thin skin, or oxidative stress. Polynucleotides enhance microcirculation and promote cellular oxygenation, leading to a brighter, more even skin tone.
Additionally, they help strengthen the delicate capillaries under the eyes, reducing the appearance of blue or purple undertones. Because Polynucleotides also have anti-inflammatory properties, they calm irritation and pigmentation that may contribute to darker shadows.
In clinical studies, patients reported a more radiant and illuminated under-eye area within just a few weeks of treatment.
Under-eye puffiness is commonly caused by fluid retention, weakened skin structure, or fat protrusion. While fillers can sometimes exacerbate puffiness by adding extra volume, Polynucleotides take a different approach; they naturally tighten and tone the skin.
By stimulating collagen and elastin production, they improve the skin’s firmness, helping reduce the visible bulge of under-eye bags. They also promote lymphatic drainage and enhance blood circulation, which minimises fluid buildup and puffiness.
The result is a smoother, more contoured under-eye area that looks rested and refreshed.
One of the hallmarks of ageing under-eye skin is a crepey, uneven texture. Polynucleotides rebuild the skin matrix from within, restoring elasticity and resilience.
As fibroblasts become more active, new collagen and elastin fibres form, improving the overall texture and tone of the under-eye area. This makes makeup application easier and enhances the skin’s natural luminosity.
The gradual improvement continues for several months as the body’s regenerative response remains active long after the treatment.
Unlike dermal fillers, which can sometimes alter facial contours or create an artificial appearance, Polynucleotides provide subtle and authentic rejuvenation. Because they work with your body’s own biological systems, the results appear progressively and look entirely natural.
Patients notice a gradual enhancement of softer lines, brighter eyes, and smoother skin without the sudden or noticeable change often associated with cosmetic injectables.
This makes Polynucleotide treatment a perfect choice for individuals seeking subtle improvement that aligns with their natural beauty.
Hydration is essential for youthful skin, especially under the eyes, where dryness can accentuate fine lines. Polynucleotides attract and retain water molecules, helping maintain deep dermal hydration.
This hydration effect gives the skin a plump, dewy finish, which enhances light reflection and diminishes the dull, tired appearance that often accompanies dehydration.
Regular treatments can help maintain long-term moisture balance, preventing the return of dryness and fatigue.
Polynucleotide treatment doesn’t just offer temporary results; it encourages the skin to continue regenerating over time. Once fibroblast activity is stimulated, its effects can last for six to twelve months or longer, depending on the individual’s skin condition.
With periodic maintenance sessions, patients can enjoy continuously rejuvenated under-eye skin, maintaining brightness, firmness, and smoothness well into the future.
This regenerative process sets Polynucleotides apart from many other treatments that require frequent top-ups or offer short-lived effects.
Understanding the treatment journey is crucial for anyone considering Polynucleotide therapy for the under-eye area. Unlike fillers that deliver instant volume, this treatment stimulates your skin’s natural repair systems, so results develop gradually but last longer. Below is a detailed, step-by-step explanation of what to expect throughout the process.
Every Polynucleotide treatment begins with a professional consultation. This stage ensures the treatment plan aligns with your unique skin condition, goals, and medical history.
During your consultation, the practitioner will:
This stage is essential for setting realistic expectations and determining if Polynucleotide therapy alone or in combination with other treatments (e.g., microneedling or PRP) is ideal for you.
To ensure optimal results and reduce the risk of bruising or swelling:
Following these simple steps helps prepare your skin for maximum absorption and minimal irritation.
Polynucleotide therapy for the under-eye area is a minimally invasive, quick, and comfortable procedure when performed by a trained aesthetic professional.
The treatment begins with a thorough cleansing of the under-eye region. A topical numbing cream is applied to ensure comfort during the injection process. Most patients describe the sensation as mild pressure or pinching rather than pain.
The practitioner uses ultra-fine needles to deliver small amounts of the Polynucleotide solution just beneath the skin’s surface. These precise microinjections are distributed evenly across the treatment area, targeting regions with fine lines, pigmentation, or dehydration.
Some clinics may use microcannulas (tiny flexible tubes) instead of needles to reduce bruising and increase comfort.
A typical under-eye Polynucleotide session lasts about 20 to 40 minutes, depending on individual needs.
Once complete, the treated area may appear slightly red or puffy. This is normal and usually subsides within a few hours.
Polynucleotide treatments are known for their minimal downtime. Most clients resume normal activities shortly after their session, though following post-care instructions is essential for optimal healing.
Following these guidelines helps reduce redness and ensures smooth recovery.
Polynucleotide treatment stimulates the skin’s biological repair process, so results develop progressively:
Because the process relies on natural regeneration, patience is key. The effects are subtle but enduring.
For best results:
Consistent follow-ups help the skin remain youthful and resilient in the long term.
Polynucleotide therapy integrates beautifully with other non-surgical aesthetic procedures:
Combination therapy must be planned carefully to avoid overstimulation or inflammation; always follow the guidance of a professional.
Polynucleotide therapy has quickly become a go-to solution for individuals seeking to naturally rejuvenate their under-eye skin without relying on fillers, surgery, or aggressive lasers. However, like any aesthetic treatment, it’s most effective when performed on the right candidates. Understanding who benefits most helps set realistic expectations and ensures optimal, long-lasting results.
This treatment is highly versatile and suitable for a wide range of adults, but it’s particularly beneficial for individuals experiencing:
Polynucleotide injections stimulate fibroblasts, the cells responsible for producing collagen and elastin in the skin. This process smooths fine lines and early wrinkles, especially those caused by repetitive facial movement or sun exposure.
If you’ve noticed creasing, crow’s feet, or changes in under-eye texture, Polynucleotide therapy can help restore firmness and elasticity in a natural, non-invasive way.
The under-eye area is prone to dryness because it contains fewer oil glands than other areas of the face. Polynucleotides act as internal hydrators, drawing and retaining moisture within the skin. This deep hydration revives dull, tired-looking eyes, helping the skin appear brighter, smoother, and more radiant.
While some dark circles are due to pigmentation, many arise because of thin skin revealing underlying blood vessels. Polynucleotides strengthen the dermal matrix, thickening the skin and improving microcirculation. This leads to a more even tone and reduced shadowing, particularly in cases caused by skin thinning rather than melanin overproduction.
If your dark circles worsen with fatigue or age but not from genetic pigmentation, Polynucleotide therapy may be especially effective.
Polynucleotides help balance the skin’s inflammatory response and improve lymphatic drainage. For patients with mild puffiness caused by fluid retention or tissue laxity (not fat prolapse), this therapy can visibly reduce swelling and tighten the under-eye contour.
However, in cases of severe eye bags due to fat herniation, surgical options like blepharoplasty might be more appropriate.
You don’t need deep wrinkles to benefit from Polynucleotides. Many people in their late 20s to early 30s choose this treatment preventively, to preserve collagen levels and delay the onset of visible ageing.
Think of it as future-proofing your skin, strengthening the dermal foundation before signs of fatigue, sagging, or dullness appear.
Polynucleotide injections also work beautifully as part of recovery plans following resurfacing procedures, chemical peels, or microneedling. Their anti-inflammatory and healing properties help repair the skin barrier and accelerate cell turnover, reducing downtime and improving final results.
Although generally very safe, Polynucleotide therapy isn’t recommended for everyone. You should avoid or postpone treatment if you:
During consultation, your practitioner will review your medical background to confirm whether Polynucleotides are right for you.
While there’s no strict age limit, Polynucleotide treatments are most effective for people aged 25–60, depending on skin quality:
No matter your age, Polynucleotides can provide a subtle, natural lift when tailored correctly to your skin’s condition.
One of the standout advantages of Polynucleotides is that they are safe for all skin tones and types. Since the treatment focuses on cellular repair rather than pigmentation or surface peeling, it carries minimal risk of post-inflammatory hyperpigmentation — a concern common in darker skin tones.
This universal compatibility makes it a trusted option across diverse patient profiles.
Under-eye rejuvenation has evolved from traditional fillers to advanced regenerative therapies. Polynucleotide treatment stands out because it not only masks imperfections but also stimulates the skin’s natural repair process. Here’s how it compares with other popular under-eye treatments.
How They Work:
Key Differences:
Verdict:
If you want quick results for deep hollows, fillers are a practical option. For long-term rejuvenation, firmness, and brightness, Polynucleotides are the better choice.
How They Work:
Key Differences:
Verdict:
Both are regenerative, but Polynucleotides provide superior hydration and structure restoration, making them ideal for delicate under-eye skin.
How They Work:
Key Differences:
Verdict:
Skin boosters refresh the skin; Polynucleotides transform it. They provide longer-lasting results and strengthen skin over time.
How They Work:
Key Differences:
Verdict:
If you need surface texture correction, lasers can be a helpful solution. For gentle, deep rejuvenation and repair, Polynucleotides are safer and more versatile.
How They Work:
Key Differences:
Verdict:
Microneedling helps improve texture, but Polynucleotides are gentler and more effective for the fragile under-eye area.
How They Work:
Key Differences:
Verdict:
Eye creams are excellent for maintenance, but can’t replace the biological rejuvenation provided by Polynucleotides. Together, they create the best results.
Polynucleotide treatment may sound scientific, but in practice, it’s a safe, straightforward, and minimally invasive procedure. The process is designed to rejuvenate under-eye skin by stimulating your body’s natural healing and regenerative mechanisms. Understanding what happens before, during, and after treatment helps clients feel confident and know what to expect.
Every treatment begins with a detailed consultation.
A qualified aesthetic professional examines the under-eye area and discusses your:
The practitioner determines whether Polynucleotides are suitable and creates a personalised treatment plan, including the number of sessions required and the spacing between them.
Before the session:
The treatment area must remain sterile at all times to prevent irritation or infection.
The actual procedure is quick and comfortable, typically taking around 20 to 30 minutes.
Here’s how it works step-by-step:
The injections may create small visible bumps or mild swelling immediately afterwards — this is entirely normal and subsides within a few hours.
After the treatment:
Post-treatment care tips:
By following these steps, you help ensure faster healing and optimal absorption of Polynucleotides.
For best results, most professionals recommend a course of 3 to 4 treatments, spaced about 2 to 4 weeks apart.
After completing the initial course, regular maintenance sessions, every 6–9 months, help sustain skin firmness and radiance.
Unlike fillers that show instant results, Polynucleotides work gradually.
The improvements continue to develop even after the treatment course is finished, as the skin’s cellular renewal process remains active.
Polynucleotide injections are generally very safe, primarily when performed by a trained professional. Still, like any aesthetic treatment, minor side effects can occur, such as:
Severe reactions are infrequent. Because Polynucleotides are biocompatible and non-allergenic, they are well-tolerated even by sensitive skin.
For enhanced under-eye rejuvenation, Polynucleotides can be safely combined with other aesthetic treatments:
Your practitioner will guide you on the best treatment combinations and recommend the most suitable scheduling.
To maintain the benefits of Polynucleotide therapy:
Polynucleotides not only rejuvenate but also strengthen the skin’s resilience over time, making future ageing less visible.
The under-eye area has always been one of the most delicate and challenging regions to treat in aesthetic medicine. Traditional approaches, such as fillers, creams, or laser resurfacing, often yield mixed results or risk unnatural outcomes. Polynucleotide therapy changes that by addressing the root cause of ageing and skin fatigue at a cellular and regenerative level.
Rather than simply filling hollows or tightening skin temporarily, Polynucleotides restore biological balance, prompting the skin to rebuild itself from within. This makes the results not only more natural and gradual but also longer-lasting. The improvement in collagen production, microcirculation, and hydration helps the under-eye area look brighter, smoother, and more resilient over time.
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